A facile synthesis of water-soluble BaYF5:Ln3+ NCs with excellent luminescent properties as promising contrast agent for dual-modal bioimaging

Monodisperse, water-dispersible lanthanide (Ln3+)-doped BaYF5 nanocrystals (NCs) are synthesized through a fast, facile and environmentally–friendly microwave-assisted modified polyol process with polyethyleneimine as the surfactant. The TEM images illustrate the sphere-like and flower-like morpholo...

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Bibliographic Details
Published in:Inorganic chemistry communications 2015-12, Vol.62, p.11-14
Main Authors: Chen, Cailing, Li, Chunguang, Zhao, Liang, Liu, Xiaomin, Bai, Tianyu, Huang, He, Shi, Zhan, Feng, Shouhua
Format: Article
Language:English
Subjects:
Bioimaging agent
Lanthanide
Nanocrystals
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Summary:Monodisperse, water-dispersible lanthanide (Ln3+)-doped BaYF5 nanocrystals (NCs) are synthesized through a fast, facile and environmentally–friendly microwave-assisted modified polyol process with polyethyleneimine as the surfactant. The TEM images illustrate the sphere-like and flower-like morphologies of the obtained NCs. Intense multicolor down conversion (DC) luminescence is also achieved in Ce3+/Ln3+ (Ln=Tb, Dy) doped BaYF5 NCs. Then, upon excitation at 980nm, upconversion (UC) luminescent properties of BaYF5:Yb3+/Ln3+ (Ln=Er, Tm, Ho) NCs and energy transfer between Yb3+ and Ln3+ are systematically surveyed. Furthermore, a layer of SiO2 is coated on the surface of the NCs and the methyl thiazolyl tetrazolium (MTT) assays are performed to test the cytotoxicity of BaYF5:Ln3+ NCs. Due to the X-ray absorption property of Ba element, a proof-of-concept CT imaging with BaYF5:Ln3+ NCs is conducted. These results indicate that the obtained NCs have great potential as optical/CT bioprobe. Monodisperse, water-dispersible BaYF5:Ln3+ nanospheres and nanoflowers were synthesized via microwave-assisted modified polyol process. The obtained NCs with excellent up-down luminescent property and X-ray absorption property have great potential as optical/CT bioprobe. [Display omitted] •Monodisperse and uniform BaYF5:Ln3+ NCs with two different shapes are obtained.•The synthetic process is facile, convenient and environmental-friendly.•A thin layer of SiO2 is coated on BaYF5:Ln3+ NCs.•The water-soluble NCs have good luminescent properties and low cytotoxicity.
ISSN:1387-7003
1879-0259
DOI:10.1016/j.inoche.2015.10.020