A metal-organic framework with unusual nanocages: Drug delivery

An unusual nanocage-based framework of [Zn2(L)(H2O)1.5]·5H2O (1) was used as a drug carrier of 5-fluorouracil (5-FU) for drug delivery. The incorporation of drug 5-FU into the 1 was around 48.6wt% per gram of dehydrated 1. 5-FU is released in a highly controlled and progressive manner with 98% of th...

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Bibliographic Details
Published in:Inorganic chemistry communications 2017-02, Vol.76, p.91-94
Main Authors: Luo, Zhidong, Wang, Rui, Gu, Chuying, Li, Fumei, Han, Yaoyao, Li, Baohong, Liu, Jianqiang
Format: Article
Language:English
Subjects:
Cytotoxicity assay
Drug delivery
Nanocage
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Summary:An unusual nanocage-based framework of [Zn2(L)(H2O)1.5]·5H2O (1) was used as a drug carrier of 5-fluorouracil (5-FU) for drug delivery. The incorporation of drug 5-FU into the 1 was around 48.6wt% per gram of dehydrated 1. 5-FU is released in a highly controlled and progressive manner with 98% of the drug release after 101h at acidic condition and with 62% after 72h at PBS. 1 did not exhibit any significant cytotoxicity using the vitro cytotoxicity assays. The result from this study suggested a new approach for MOFs to be used as potential drug delivery. A new MOF was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The cargo release behavior and material degradation profile were also investigated under different pH. [Display omitted] •Compound 1 shows two unusual nanocages.•It incorporates the drug 5-FU with 48.6wt%.•5-FU is released in a highly controlled and progressive manner.
ISSN:1387-7003
1879-0259
DOI:10.1016/j.inoche.2017.01.002