The antitumor effect and toxicity of a ruthenium(II) complex in vivo

The toxicity and antitumor activity of a ruthenium(II) complex [Ru(dmp)2(ipad)](ClO4)2 (Ru1) was evaluated. In vivo experiments demonstrated that Ru1 dose-dependently inhibited growth of a human liver carcinoma cell line (BEL-7402) that was xenotransplanted into nude mice. TUNEL assays showed that R...

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Bibliographic Details
Published in:Inorganic chemistry communications 2018-01, Vol.87, p.49-52
Main Authors: Wang, Jinquan, Zhao, Zizhuo, Zhou, Shu, Zhang, Xianhuan, Bo, Huaben
Format: Article
Language:English
Subjects:
Antitumor
Mice
Ruthenium(II) complexes
Toxicity
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Summary:The toxicity and antitumor activity of a ruthenium(II) complex [Ru(dmp)2(ipad)](ClO4)2 (Ru1) was evaluated. In vivo experiments demonstrated that Ru1 dose-dependently inhibited growth of a human liver carcinoma cell line (BEL-7402) that was xenotransplanted into nude mice. TUNEL assays showed that Ru1 induced apoptosis in tumor tissue cells. However, a toxicological examination indicated that high doses of Ru1 can cause kidney damage and lead to elevated levels of serum creatinine. In addition, Ru1 appeared to be genotoxic and hematologically toxic in a dose-dependent manner. The obtained results provided basic information regarding the further design of ruthenium(II) antitumor drugs. A ruthenium(II) complex Ru1 showed antitumor activity in mice, but it had toxic effects on the kidney, blood and bone marrow cells on treated mice. [Display omitted] •A novel ruthenium(II) complex Ru1 inhibited growth of a human liver carcinoma cell line dose-dependently in vivo.•TUNEL assays showed that Ru1 induced apoptosis in tumor tissue cells.•Ru1 can cause kidney damage, genotoxicity and hematological toxicity.
ISSN:1387-7003
1879-0259
DOI:10.1016/j.inoche.2017.12.003