Y2O3/HAp, a sustainable catalyst for novel synthesis of furo[3,4-b]chromenes derivatives via green strategy

• Published in: Inorganic chemistry communications 2020-04, Vol.114, p.107807, Article 107807
• Main Authors: Ganja, Himavathi, Robert, Alice R., Lavanya, Palakondu, Chinnam, Sampath, Maddila, Suresh, Jonnalagadda, Sreekantha B.
• Format: Article
• Language: English
• Subjects: Green synthesis; Heterocyclic molecules; Heterogeneous Catalysts; One-pot reaction
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2020.107807

[Display omitted] •A facile and green synthesis of furo[3,4-b]chromene derivatives with excellent yields.•Efficient protocol using green solvent and reusable Y2O3/HAp catalyst with short reaction times.•Nontoxic solvent and cost effective reagents. A green, facile and multicomponent reaction for the preparation of furo[3,4-b]chromenes using a recoverable and reusable yttria doped hydroxyapatite (Y2O3/HAp) solid material as the heterogeneous catalyst is described. The reaction progresses with mixing the aldehyde, 4-hydroxyfuran-2(5H)-one, 5,5-dimethylcyclohexane-1,3-dione and Y2O3/HAp at R.T. in ethanol solvent media to obtain the desired target molecules in excellent yields (91–98%). The proposed approach shows noteworthy benefits such as ecofriendly, non-toxic solvents, easy handling, short reaction time (10 min), simple workup procedure, avoiding column chromatography and reusability of the catalyst, proving vital green chemistry principles.