Transition metal complexes of ligand 4-imino-3-[(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)diazenyl]-4H pyrimido[2,1-b][1,3]benzothiazol-2-ol containing benzothiazole moiety: Synthesis, spectroscopic characterization and biological evaluation

• Published in: Inorganic chemistry communications 2021-05, Vol.127, p.108524, Article 108524
• Main Authors: Rangappa, Maliyappa M., Keshavayya, Jathi, Murali Krishna, Panchangam, Rajesh, K.
• Format: Article
• Language: English
• Subjects: Anticancer; Antituberculosis; Azo dye; Benzothiazole; DNA binding
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2021.108524

[Display omitted] •Synthesis of some bioactive metal complexes derived from azo ligand [HL].•Structures of the newly synthesized molecules were elucidated by various spectroscopic and analytical techniques.•All the studied molecules exhibited significant biological properties such as anti-mycobacterial, DNA binding and anticancer studies. A series of novel metal [Cu(II), Co(II), Ni(II) and Zn(II)] complexes have been prepared with an azo ligand, 4-imino-3-[(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)diazenyl]-4Hpyrimido[2,1b][1,3]benzothiazol-2-ol [HL] derived from benzothiazole nucleus. The newly synthesized complexes were characterized by investigating various spectroscopic and analytical techniques such as UV–Vis, FT-IR, 1H NMR, Mass, Powder-XRD, TGA, ESR, SEM, EDAX and VSM (Vibrating Sample Magnetometer). The azo ligand and its metal complexes have been investigated for their anti-tuberculosis, anticancer and DNA binding studies. The tested compounds showed moderate to good antituberculosis activity compared with the standards. In addition, all the prepared compounds exhibited a significant hypochromicity and considerable groove-binding property to the CT-DNA. The anticancer activity of the Zn(II) complex exhibited IC50 value less than 50 compared to other compounds against A549 and K562 cell lines.