Green facile synthesis of silver-doped cerium oxide nanoparticles and investigation of their cytotoxicity and antibacterial activity

• Published in: Inorganic chemistry communications 2021-09, Vol.131, p.108762, Article 108762
• Main Authors: Maleki, Parisa, Nemati, Fahimeh, Gholoobi, Aida, Hashemzadeh, Alireza, Sabouri, Zahra, Darroudi, Majid
• Format: Article
• Language: English
• Subjects: Ag doping; Antibacterial; Cerium oxide nanoparticles; Cytotoxicity; Green synthesis; Salvia seeds
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2021.108762

[Display omitted] •An eco-friendly and cost-effective procedure for silver-doped cerium oxide nanoparticles.•Low cell bio-toxicity of the silver-doped cerium oxide nanoparticles.•The investigation of antibacterial activity of the silver-doped cerium oxide nanoparticles. Cerium oxide (CeO2) nanoparticles and silver-doped cerium oxide (Ce1-xAgxO2) were produced via a green bioprocess by water extract of Salvia seeds as a capping agent without using any alkaline agent. Various procedures such as FT-IR, FESEM, EDX, TGA/DTG, and XRD were applied for the structure determination and morphology of synthesized Ce1-xAgxO2 nanoparticles. The outcomes show that synthesized nanoparticles have a uniform spherical morphology and a size average of 62 nm. The in vitro cytotoxicity effect of Ce1-xAgxO2 nanoparticles was investigated on the EPG human gastric cancer cell line which was detected in the treated EPG human gastric cancer cell to be up to 62.5 mM. Also, the synthesized nanoparticles were used to study antibacterial activity against pathogenic bacteria (Staphylococcus aureus and Pseudomonas aeruginosa).