Biosynthesis of lead oxide and cerium oxide nanoparticles and their cytotoxic activities against colon cancer cell line

• Published in: Inorganic chemistry communications 2021-09, Vol.131, p.108800, Article 108800
• Main Authors: Nazaripour, Ebrahim, Mousazadeh, Farideh, Doosti Moghadam, Mehdi, Najafi, Kazem, Borhani, Fariba, Sarani, Mina, Ghasemi, Masoomeh, Rahdar, Abbas, Iravani, Siavash, Khatami, Mehrdad
• Format: Article
• Language: English
• Subjects: Bioethics principles; CeO2 nanoparticles; Cytotoxic assay; PbO nanoparticles; Safe
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2021.108800

[Display omitted] •Green synthesis of PbO and CeO2 NPs using Prosopis fracta fruit.•Formation of PbO and CeO2 NPs confirms using PXRD, FT-IR, FESEM, and UV–Visible studies.•The green synthesized PbO and CeO2 NPs were scaled in nano in the size range about 25–30 nm and 15–20 nm, respectively.•The cytotoxic activity exhibited that PbO and CeO2 nanoparticles were non-toxic in below concentration of 500 and 62.5 µg/mL, respectively. Green synthesis of nanoparticles is considered as a potential and efficient choice compared to chemical and physical ways for the preparation of nanoparticles due to important advantages such as eco-friendliness, safety, simplicity, cost-effectiveness, up-scalable potentials, and also is according bioethics principles. In this study, cerium oxide (CeO2) and lead oxide (PbO) nanoparticles were prepared in a green approach by aqueous extract of Prosopis fracta fruit. The structure and morphology of prepared nanoparticles were confirmed using PXRD, UV–Vis, FT-IR, TEM, EDX, and FESEM analyses. The cytotoxic activity of PbO and CeO2 nanoparticles was studied on colon (HT-29) cancer cell lines. Based on the obtained results, PbO and CeO2 nanoparticles were non-toxic in below concentration of 500 and 62.5 µg/mL, respectively. Notably, these nanoparticles can play vital roles in biological assays, and further studies should be performed on their cytotoxic evaluations, in vivo.