Synthesis, structural characterization and selective anticancer activity of [AgI(L)(PPh3)]2(NO3)2 [L = N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone]

[Display omitted] •Silver(I)•Thiosemicarbazone.•Synthesis.•Structural characterization.•Selective anticanceractivity. A dinuclear silver(I) complex [Ag(L)(PPh3)]2(NO3)2 [L = 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone] (1) has been synthesized and X-ray crystallographically characterized. From...

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Published in:Inorganic chemistry communications 2022-02, Vol.136, p.109178, Article 109178
Main Authors: Biswas, Chinmoy, Chatterjee, Arnab, Vijayan, Vinu, Purohit, Chandra Shekhar, Kiran, Manikantan Syamala, Ghosh, Rajarshi
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Language:English
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Ag(I)
Cytotoxicity
ROS
Thiosemicarbazone
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container_title Inorganic chemistry communications
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description [Display omitted] •Silver(I)•Thiosemicarbazone.•Synthesis.•Structural characterization.•Selective anticanceractivity. A dinuclear silver(I) complex [Ag(L)(PPh3)]2(NO3)2 [L = 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone] (1) has been synthesized and X-ray crystallographically characterized. From X-ray structural characterization each of the Ag(I) centers in 1 has been found to have distorted square pyramidal structure. The compound 1 is found to show selective anticancer activity against liver cancer cells Hepa1-6. The reactivity of 1 against the cancer cells was found through formation of Reactive Oxygen Species (ROS) induced mitochondrial death.
doi_str_mv 10.1016/j.inoche.2021.109178
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subjects Ag(I)
Cytotoxicity
ROS
Thiosemicarbazone
title Synthesis, structural characterization and selective anticancer activity of [AgI(L)(PPh3)]2(NO3)2 [L = N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone]
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