Green tea extract bio-templated synthesis of Ag NPs immobilized magnetic nanocomposite: Evaluation of its catalytic activity and its performance for the treatment of gastrointestinal system cancers

• Published in: Inorganic chemistry communications 2023-09, Vol.155, p.111092, Article 111092
• Main Authors: Wang, Mingqing, Zhou, Weiguo, Cao, Wei, Yang, Kang, Zhang, Zehua, Zhang, Xun, Xiong, Maoming
• Format: Article
• Language: English
• Subjects: Alcohols; Fe3O4@CLS/Ag; Gastrointestinal; Green tea extract; O-Acetylation
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2023.111092

[Display omitted] •Green supported of silver nanoparticles silver nanoparticles over calcium lignosulfonate functionalized Fe3O4 nanocomposite mediated by green tea extract.•Green tea extract act as a reducing and stabilizing agent without any toxic regents.•Fe3O4@CLS/Ag nanocomposite was prepare and characterized.•Fe3O4@CLS/Ag nanocomposite shown good antioxidant and anti-gastrointestinal system cancers. Plant based biogenic synthesized nanocomposites have been the most featured materials these days, particularly in the medical arena. This particular report expresses a sustainable methodology for the in situ synthesis of silver nanoparticles (Ag NPs) adorned calcium lignosulfonate functionalized Fe3O4 nanocomposite mediated by green tea extract (Fe3O4@CLS/Ag) and its subsequent chemical and biological applications. Structural and physicochemical features of the novel material was evaluated through a number of analytical techniques like SEM, TEM, EDX, elemental mapping, VSM and ICP-OES. The nanocomposite material was a found to be proficient catalyst towards the O-acetylation of a range of alcohols and phenols using acetic anhydride under solvent-free conditions. The nanocatalyst was so robust that it could be recycled for 9 consecutive times without much decrease in reactivity. Towards the bioapplication, the material was explored in the determination of cytotoxicity against gastrointestinal system cancers like colon, pancreas and gastric. The Fe3O4@CLS/Ag nanocomposite could significantly restrict the proliferation of malignant cells like Ramos.2G6.4C10 (Colorectal cancer), HPAF-II (Pancreatic cancer) and GC1415 (Gastric cancer) cell lines, as determined by in vitro MTT assay. The corresponding IC50 were found as 381, 277 and 340 µg/mL against the three cell lines. Furthermore, the antioxidant capacity of Fe3O4@CLS/Ag was determined by DPPH method which displayed a significant activity as per IC50 value. The significant outputs obtained in the chemical and biological application of the material justifies its novelty and validates its large scale industrial competence and potent chemotherapeutic applications.