MoS2/Polymer nanotube composite material used for the electrochemical sensor detection of biologically active compounds

• Published in: Inorganic chemistry communications 2023-10, Vol.156, p.111228, Article 111228
• Main Authors: Ganesha, H., Veeresh, S., Nagaraju, Y.S., Devendrappa, H.
• Format: Article
• Language: English
• Subjects: Ascorbic acid; Binding energy; Dopamine; Electrochemical sensors; Molybdenum disulfide-polyaniline nanotube; Morphology
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2023.111228

[Display omitted] •The fabricated MPN-1 and MPN-2 GCE, and MoS2 GCE electrode demonstrated the good oxidation activity towards the detection of DA and AA analytes.•The MPN-1 GCE shows simultaneous detection of DA and AA with a wide linear range from 5 to 60 µM, and a low limit of detection of 0.92 µM, and 1.42 µM, and the real sample analysis showed that the good recovery range of 96.96 % to 104.73 %, and RSD of less than 2.7 %. In this study demonstrates, molybdenum disulfide/polyaniline nanotube (MPN) composite was synthesized by Co-precipitate and hydrothermal chemical route with a controlled pH value of the solution. The synthesized novel material used to develop new generations of high efficiency electrochemical sensors because of their tuneable physico-chemical properties and distinctive surface morphology, which may provide a large surface area that, allows various analytes for simultaneous detection. The fabricated MPN electrochemical sensor used for examining simultaneous detection of dopamine (DA) and ascorbic acid (AA) may help to find the neuro system cause, and small molecules play a key role in the living organism or human body. The MPN composite chemical interactions and functional groups are identified through the Fourier transform infrared spectra (FTIR) method. The surface morphology of the nanotube was examined by using Field emission scanning electron microscope (FESEM) and High resolution transmission electron microscope (HR-TEM) techniques. The X-ray photoelectron spectroscopy (XPS) spectrum identifies the C, N, Mo, and S elements present in the composite material. The cyclic voltammetry (CV) curve shows a quasi-reversible redox reaction, and the Nyquist plot exhibits the perfect semi-circle. The MPN glassy carbon electrode (GCE) shows simultaneous detection of DA and AA with an achieved linear range of 5 µM–60 µM, and possesses a low limit of detection of 0.92 µM, and 1.42 µM. The developed sensor electrode is used for DA and AA determination in human blood serum samples with an excellent recovery range of 96.96 % to 104.73 % and an RSD of less than 2.7 % in real sample analysis, these results suggest that the MPN-1 GCE shows a potential candidate towards the accurate determination of DA and AA in neuro system applications.