Design, synthesis, characterization, spectral, chemical analysis, biological evaluation, and molecular docking studies of novel fatty Schiff base ligands and their nickel and mercury complexes

• Published in: Inorganic chemistry communications 2023-12, Vol.158, p.111382, Article 111382
• Main Authors: H. Taha, Rania, Alrabie, Ali, Badr, E.E., M.N., Shymaa, Baker, Sharbat A.
• Format: Article
• Language: English
• Subjects: Activity against bacteria; Against fungi; Diffraction of X-rays; Diffusion of discs and molecular docking; Gram-positive bacteria and a gram-Negative; Schiff base ligand
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2023.111382

[Display omitted] •A novel two Fatty Schiff bases ligands and their complexes with Hg and Ni were synthesized.•The novel synthesized compounds were characterized by 1HNMR, FT-IR, spectroscopy, elemental analysis, Diffraction of X-rays, and thermal evaluation.•In-vitro strains have been used to study their antibacterial properties.•In the comparison of free ligands with their complexes. The latter was a more potent antibacterial agent and was more efficient against gram-positive bacteria than gram-negative bacteria.•Additionally, investigations using molecular docking have been carried out to assess the ideal binding location and its inhibitory effect. A novel two Fatty Schiff bases ligands of (N-(4-(dimethyl amino) benzylidene Dodecane, heptadecane) hydrazide and N-(4-(dimethyl amino) benzylidene) dodecane, heptadecan hydrazides and their complexes with Hg and Ni were synthesized and distinguish by1HNMR, FT-IR, spectroscopy, elemental analysis, X-ray Diffractions, thermal gravimetric analysis, and magnetic moments. In-vitro strains have been used to study their antibacterial properties. The ligands and their metal complexes have been evaluated physiologically by various bacterial and fungal strains. In the comparison of free ligands with their complexes. The latter were a more potent antibacterial agent and were more efficient against gram-positive bacteria than gram-negative bacteria. Additionally, investigations using molecular docking have been carried out to assess the ideal binding location and its inhibitory effect.