Non-enzymatic glucose electrochemical sensor based on nitrogen-doped graphene modified with polyaniline and Fe3O4@MIL-101-NH2 nano framework

• Published in: Inorganic chemistry communications 2024-01, Vol.159, p.111812, Article 111812
• Main Authors: Ghaffarirad, Mohammad Ali, Sabahi, Abbas, Golshani, Zeynab, Manteghi, Faranak, Ghaffarinejad, Ali
• Format: Article
• Language: English
• Subjects: Core-shell; Electrochemical; Iron oxide; Metal-organic framework; Non-enzymatic glucose sensor; Polyaniline
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2023.111812

[Display omitted] •Glucose non-enzymatic electrochemical sensor based on polyaniline, graphene and MOF.•A large surface area, enhanced electron transfer and catalytic properties.•The sensor has a wide linear range and good sensitivity.•Acceptable performance in human fluids real samples including serum and plasma. In this study, a novel highly sensitive and selective non-enzymatic glucose sensor was fabricated by coating simple and cheap graphite sheet (GS) electrodes with a proper conductive nanocomposite containing nitrogen-doped functionalized graphene (NFG), conductive polyaniline (PANI), and core–shell nanoparticles (Fe3O4@MIL-101-NH2). The results revealed that the core centers of iron oxide nanoparticles shelled by MIL-101-NH2 enhanced the electron transfer and led to more conductivity, also their existence caused the limitation of the MOF’s low conductivity. In addition, using Fe3O4@MIL-101-NH2 in the nanocomposite structure led to more sensitivity and selectivity at glucose monitoring due to its amine groups and unique structure. The results showed that NFG/PANI/Fe3O4@MIL-101-NH2 nanocomposite provided a large surface area besides enhanced electron transfer and catalytic properties that lead to proper oxidation of glucose with two linear ranges of 0.5 – 10 µM and 100 µM – 25 mM and a low detection limit of 0.3 µM (S/N = 3). Furthermore, the relative standard deviation (RSD%) in all detection processes was lower than 9 %. Finally, the performance of fabricated non-enzymatic sensor (GS/NFG/PANI/Fe3O4@MIL-101-NH2) in human fluids real samples including serum and plasma was acceptable which significantly indicates that it is toward monitoring of glucose in clinical applications.