Facile synthesis and surface characterization of platinum and gold bimetallic nanoparticles prepared using hydroalcoholic extract of Bryophyllum Pinnatum: Enhancing efficacy against breast cancer

• Published in: Inorganic chemistry communications 2024-07, Vol.165, p.112555, Article 112555
• Main Authors: Bhinge, Somnath Devidas, Pratiksha, Dange, Anil, Bhutkar Mangesh, Ramhari, Jadhav Namdeo, Rajaram, Salunkhe Vijay, Ajit, Jagtap, Gurav, Shailendra Shivaji
• Format: Article
• Language: English
• Subjects: Anticancer; Bimetallic nanoparticles; Bryophyllum pinnatum; Gold and Platinum; Green synthesis
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2024.112555

[Display omitted] •BrPi-P-G-NPs synthesized through green synthesis.•Research delves into BrPi-P-G-NPs, prepared using BrPi extract, offering novel insights.•Biogenic BrPi-P-G-NPs demonstrated notable anticancer efficacy against breast cancer cell lines.•Enhanced stability and reduced toxicity of NPs profiles showcased. Primary aim of the proposed study was to explore the green technique for synthesis of bimetallic nanoparticles of platinum and gold metal by employing Bryophyllum pinnatum hydroalcoholic extract (BrPi-P-G-NPs) to explore their potential medicinal properties. Green synthesised bimetallic nanoparticles were characterized by techniques including UV spectroscopy, XRD, FTIR, SEM, TEM, DSC, Particle size and Zeta Potential analysis. Experimental findings confirmed that BrPi-P-G-NPs demonstrate irregular shape, with an average size 34.5 nm. Zeta potential for BrPi and BrPi-P-G-NPs were found to be −8.1 and −24.1 mV, respectively. At a concentration of 75 µg mL−1, the MTT and trypan blue assays of the BrPi-P-G-NPs revealed a cell inhibition rate of 63.54 % and 60.23 %, respectively. In the MCF-7 cell line, the MTT and trypan blue assays recorded IC50 values of 153.54 and 158.04, respectively, for the BrPi-P-G-NPs at the same concentration. Thus, biologically synthesized BrPi-P-G-NPs demonstrated promising anti-cancer properties against human breast cancer cell lines, while showed no signs of toxicity. The enhanced biological activity of BrPi-P-G-NPs can be attributed to their distinctive properties at the nanoscale, as both exhibit lower polydispersity and nanoparticle size, which contribute to increased reactivity and interactions with biological systems. As a result, these BrPi-P-G-NPs nanoparticles synthesized through the biogenic approach using plant extract of Bryophyllum pinnatum have immense potential for a wide range of pharmaceutical applications.