Synthesis of new Ampicillin supported on Cr/Oxidized pectin supported on Ti bimetal–organic framework as an efficient antimicrobial and anticancer nanocomposite

• Published in: Inorganic chemistry communications 2024-07, Vol.165, p.112566, Article 112566
• Main Authors: Hsu, Chou-Yi, Ali, Eyhab, Thoulfikar A.Alamir, Hassan, Abed Jawad, Mohammed, Alsaadi, Salim B., Morad Karim, Manal, Ali khalil, Noor Alhuda Mohammad, Alshahrani, Mohammad Yahya, Alawadi, Ahmed
• Format: Article
• Language: English
• Subjects: Anticancer activity; Antimicrobial activity; Bimetal–organic frame work; Chrome; Nanocomposite; Titanium
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2024.112566

[Display omitted] •New Ampicillin supported on Cr/Oxidized pectin supported on Ti bimetal–organic framework was synthesized.•By using TGA/DTG, FT-IR, XRD, XPS, BET, and EDAX mapping the structure of the products were characterized.•Thermal stability up to 200 °C, particle size of 75 nm and the specific surface area of 27.700 m2/g were observed.•Antibacterial and anticancer activity of synthesized nanocomposite were evaluated.•High biological activity of synthesized nanocomposite were observed.•In antibacterial activity MIC between 2–64 μg/ml in anticancer properties IC50 of 183 μg/ml were observed. To synthesize, develop and provide advanced materials with unique properties, in this study, new bimetal–organic framework nanocomposites using Titanium, chromium, oxidized petin and ampicillin were synthesized. With TGA/DTG, FT-IR, XRD, XPS, BET, and EDAX mapping, the structure of the newly synthesized compound was identified, and its structural features were reported. The thermal stability up to 200 °C, particle size of 82 nm and the specific surface area of 27.700 m2/g was from the specifications of the final product. Antimicrobial properties of different bacterial and fungal species and anticancer properties on breast cancer cells were evaluated. In biological evaluation, the synthesized nanocomposites have unique activity and was more effective than some commercial drugs. In antimicrobial activities, MIC was observed between 2–64 μg/mL and in anticancer properties IC50 of 183 μg/mL.