In-situ eco-friendly synthesis of a biomimetic robust antibacterial nanohybrid via catecholamine-induced metallization

• Published in: Inorganic chemistry communications 2024-12, Vol.170, p.113172, Article 113172
• Main Authors: Kensel Rajeev, A., Sathish, N., Elango, Hemanathan, Sivagnanam, Subramaniyam, Nayak, Suman, Das, Priyadip, Saha, Abhijit
• Format: Article
• Language: English
• ISSN: 1387-7003
• DOI: 10.1016/j.inoche.2024.113172

A robust antibacterial nano-hybrid, silver-polydopamine (Ag-PDA) nanoparticle, is formed based on a catecholamine-induced metallization reaction. The synthetic way used to prepare the nano-hybrid is devoid of harmful chemicals and it does not generate byproducts detrimental to the environment. This is a simple but completely new way of synthesizing robust antibacterial agents. The particles are negatively charged, and their average size is about 35.3 nm. The Ag-PDA nano-hybrid has potent antibacterial activity, as observed from the zone of inhibition study. The antibacterial power of the nanohybrid is higher than the Ag NPs due to the synergistic effect of polydopamine (PDA). The 62.5 ppm of Ag-PDA particles inhibit >90 % of the bacterial growth. The bacterial attachment on a surface can be reduced by 99 % using the particle. [Display omitted] •We described in the manuscript a simple new technique of synthesis of antibacterial agent from silver nitrate and dopamine hydrochloride.•A robust antibacterial nano-hybrid, silver-doped polydopamine (Ag-PDA) particle, is formed based on a catecholamine-induced metallization reaction.•The nano-hybrid was synthesized by mixing dopamine and silver nitrate only.•The synthetic way used to prepare the nano-hybrid is devoid of harmful chemicals and it does not generate byproducts detrimental to the environment.•The Ag-PDA particles (1 mg/ml) can remove 99 % of gram-positive S. aureus and gram-negative E. coli bacteria from the solution and glass surface. Antimicrobial resistance and biofilm formation on various surfaces pose serious economic and health threats. Silver nanoparticles (Ag NPs) are well known for their antibacterial application. However, the chemical synthesis of Ag NPs is not environmentally friendly and the antibacterial activity is very low. In this manuscript, we used a new technique, catecholamine-induced metallization, to prepare a robust antibacterial nanohybrid, silver-polydopamine (Ag-PDA) nanohybrid. The antibacterial power of the nanohybrid is higher than the Ag NPs due to the synergistic effect of polydopamine (PDA). The 62.5 ppm of Ag-PDA particles inhibit >90 % of the bacterial growth. The bacterial attachment on a surface can be reduced by 99 % using the particle. In this manuscript, we report the synthesis, characterization, antibacterial, and anti-biofilm effects of Ag-PDA particles.