Dietary soy isoflavone attenuated growth performance and intestinal barrier functions in weaned piglets challenged with lipopolysaccharide

This study was conducted to investigate the protective roles of soy isoflavone in weaned pigs challenged with lipopolysaccharide (LPS). A total of 72 weaned piglets (14days of age) were randomly allotted into either 0 (control group) or 40mg/kg soy isoflavone (ISO) supplementation group. On days 7 a...

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Bibliographic Details
Published in:International immunopharmacology 2015-09, Vol.28 (1), p.288-294
Main Authors: Zhu, Cui, Wu, Yunpeng, Jiang, Zongyong, Zheng, Chuntian, Wang, Li, Yang, Xuefen, Ma, Xianyong, Gao, Kaiguo, Hu, Youjun
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Diarrhea - chemically induced
Diet
Gene Expression - drug effects
Glycine max - chemistry
Growth - drug effects
Intestinal barrier function
Intestinal Mucosa - drug effects
Isoflavones - pharmacology
Lipopolysaccharides - antagonists & inhibitors
Lipopolysaccharides - pharmacology
LPS
Male
Malondialdehyde - blood
Soy isoflavone
Swine
Tight junction
Tight Junction Proteins - biosynthesis
Weaned piglets
Weaning
Weight Gain - drug effects
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Summary:This study was conducted to investigate the protective roles of soy isoflavone in weaned pigs challenged with lipopolysaccharide (LPS). A total of 72 weaned piglets (14days of age) were randomly allotted into either 0 (control group) or 40mg/kg soy isoflavone (ISO) supplementation group. On days 7 and 14, half of the pigs in each group were challenged with LPS. Soy isoflavone increased average daily gain (ADG) and average daily feed intake (ADFI) of piglets challenged with LPS at days 7–14 (P
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2015.04.054