The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer

• Published in: International immunopharmacology 2023-01, Vol.114, p.109581, Article 109581
• Main Authors: Arif, Anam, Alameri, Ameer A., Tariq, Umer Bin, Ansari, Shakeel Ahmed, Sakr, Hader Ibrahim, Qasim, Maytham T., Aljoborae, Fadhil F.M., Ramírez-Coronel, Andrés Alexis, Jabbar, Hijran Sanaan, Gabr, Gamal A., Mirzaei, Rasoul, Karampoor, Sajad
• Format: Article
• Language: English
• Subjects: Animals; Cancer; Cell Cycle Proteins - metabolism; Chemoresistance; Humans; Mammals; Neoplasms - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Protein Serine-Threonine Kinases - metabolism; Repressor Proteins - metabolism; Signal Transduction; TRIB3
• ISSN: 1567-5769; 1878-1705
• DOI: 10.1016/j.intimp.2022.109581

•TRIB3 may exhibit both oncogenic and onco-suppressor properties in various cancers.•TRIB3 has a crucial role in regulating many signaling pathways in cancer.•TRIB3 might lead to novel ways of cancer therapy.•TRIB3 is a critical determinant of radioresistance in cancer such as esophageal squamous cell carcinoma.•TRIB3 is responsible for regulating many physiological functions such as differentiation and proliferation of cells the metabolism. Currently, cancer ranks as the second leading cause of death worldwide, and at the same time, the burden of cancer continues to increase. The underlying molecular pathways involved in the initiation and development of cancer are the subject of considerable research worldwide. Further understanding of these pathways may lead to new cancer treatments. Growing data suggest that Tribble’s homolog 3 (TRIB3) is essential in oncogenesis in many types of cancer. The mammalian tribbles family's proteins regulate various cellular and physiological functions, such as the cell cycle, stress response, signal transduction, propagation, development, differentiation, immunity, inflammatory processes, and metabolism. To exert their activities, Tribbles proteins must alter key signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/AKT pathways. Recent evidence supports that TRIB3 dysregulation has been linked to various diseases, including tumor development and chemoresistance. It has been speculated that TRIB3 may either promote or inhibit the onset and development of cancer. However, it is still unclear how TRIB3 performs this dual function in cancer. In this review, we present and discuss the most recent data on the role of TRIB3 in cancer pathophysiology and chemoresistance. Furthermore, we describe in detail the molecular mechanism TRIB3 regulates in cancer.