Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy

Topical therapeutic options for cutaneous squamous cell carcinoma in situ include 5-fluorouracil cream and imiquimod cream. Such treatment may be preferable to surgical or destructive modalities in certain anatomic locations and in instances where patients are unwilling or poor surgical candidates....

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2006-12, Vol.55 (6), p.1092-1094
Main Authors: Ondo, Andrew L., Mings, Steven M., Pestak, Regina M., Shanler, Stuart D.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Aged
Aminoquinolines - administration & dosage
Aminoquinolines - pharmacology
Antimetabolites, Antineoplastic - pharmacology
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Carcinoma in Situ - drug therapy
Carcinoma, Squamous Cell - drug therapy
Cytokines - physiology
Dermatology
Drug Evaluation
Drug Synergism
Fingers
Fluorouracil - administration & dosage
Fluorouracil - pharmacology
Humans
Male
Medical sciences
Middle Aged
Ointments
Prodrugs - pharmacokinetics
Remission Induction
Skin Neoplasms - drug therapy
Toll-Like Receptor 7 - antagonists & inhibitors
Toll-Like Receptor 8 - antagonists & inhibitors
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Topical therapeutic options for cutaneous squamous cell carcinoma in situ include 5-fluorouracil cream and imiquimod cream. Such treatment may be preferable to surgical or destructive modalities in certain anatomic locations and in instances where patients are unwilling or poor surgical candidates. We present 4 such patients with cutaneous squamous cell carcinoma in situ involving a digit. Each patient failed treatment with imiquimod cream as monotherapy. In addition, two patients failed treatment with 5-fluorouracil cream as monotherapy. All 4 responded completely to 5-fluorouracil and imiquimod cream as combination therapy. In patients who have failed monotherapy with a topical agent for cutaneous squamous cell carcinoma in situ, combination treatment using both topical 5-fluorouracil cream and imiquimod cream may be considered as an alternative therapeutic strategy.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2006.06.031