Skin cancer in solid organ transplant recipients: Advances in therapy and management

The management of skin cancer in solid organ transplant recipients is a challenge to both the dermatologist and transplant physician. Part II of this continuing medical education review offers an approach to the management of this increasing problem. The importance of specialty dermatology clinics p...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2011-08, Vol.65 (2), p.263-279
Main Authors: O’Reilly Zwald, Fiona, MD, Brown, Marc, MD
Format: Article
Language:English
Subjects:
Dermatology
immunosuppression
nonmelanoma skin cancer
organ transplant recipients
radiotherapy
sentinel lymph node biopsy
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Summary:The management of skin cancer in solid organ transplant recipients is a challenge to both the dermatologist and transplant physician. Part II of this continuing medical education review offers an approach to the management of this increasing problem. The importance of specialty dermatology clinics providing access to transplant patients, frequent skin cancer screening, patient education, and multidisciplinary care is discussed. The management of low risk squamous cell carcinoma with topical therapies, photodynamic therapy, systemic retinoids, and capecitabine is reviewed. Revision of immunosuppression in the management of high-risk patients is discussed in association with the potential role of sentinel lymph node biopsy for aggressive disease. Finally, management of in-transit and metastatic squamous cell carcinoma is reviewed, with a discussion of the role of more recent innovative therapies, including epidermal growth factor receptor inhibitors in advanced squamous cell carcinoma in solid organ transplant recipients.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2010.11.063