Septal Reduction Using Transvenous Intramyocardial Cerclage Radiofrequency Ablation

• Published in: JACC. Basic to translational science 2020-10, Vol.5 (10), p.988-998
• Main Authors: Shin, Eun-Seok, Chon, Min-Ku, Jun, Eun Jung, Park, Yong-Hyun, Lee, Sang-Hyun, Kim, Jeong-Su, Shin, Dong-Hun, Lee, Soo-Yong, Cho, Min Soo, Lee, Seung-Whan, Reinthaler, Markus, Park, Jai-Wun, Nam, Gi-Byung, Lederman, Robert J., Won, Yonghyun, Kim, June-Hong
• Format: Article
• Language: English
• Subjects: echocardiography; hypertrophic cardiomyopathy; mitral cerclage; radiofrequency ablation; ventricular septum
• ISSN: 2452-302X; 2452-302X
• DOI: 10.1016/j.jacbts.2020.08.006

[Display omitted] •Surgical myectomy is morbid and transcoronary alcohol septal ablation can result in geographic miss or occasional nontarget injury.•We developed a transvenous intraseptal radiofrequency ablation technique (cerclage ablation method) to overcome the shortcomings of surgical myectomy and alcohol septal ablation.•We delivered dedicated intraseptal radiofrequency ablation catheter into the ventricular septum through the coronary sinus and a septal vein. The ablated volume of myocardium was larger at higher electrode temperatures and using an irrigated-ablation mode in vitro. Cerclage ablation was successful in all in vivo attempts and induced a focal regional wall motion abnormality at later follow-up.•This study presents in vivo evidence of the feasibility, effectiveness, and safety of cerclage ablation method to debulk interventricular septal myocardium. Debulking of left ventricular septal mass is typically accomplished using surgical myectomy, which is morbid, or using transcoronary alcohol septal ablation, which can result in geographic miss and occasional catastrophic nontarget coronary injury. The authors developed and tested operational parameters in vitro and vivo for a device to accomplish transvenous intraseptal radiofrequency ablation to reduce ventricular septal mass using a technique derived from mitral cerclage, which the authors call cerclage ablation. Cerclage ablation appeared feasible in vitro and safe and effective in vivo. Cerclage ablation is an attractive new approach to debulk the interventricular septum in obstructive hypertrophic cardiomyopathy. These data support clinical investigation.