Impact of Nesiritide on Renal Function in Patients With Acute Decompensated Heart Failure and Pre-Existing Renal Dysfunction

Impact of Nesiritide on Renal Function in Patients With Acute Decompensated Heart Failure and Pre-Existing Renal Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ronald M. Witteles, David Kao, Dianne Christopherson, Kelly Matsuda, Randall H. Vagelos, Donald Schreiber, Micha...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-11, Vol.50 (19), p.1835-1840
Main Authors: Witteles, Ronald M., MD, Kao, David, MD, Christopherson, Dianne, PhD, RN, Matsuda, Kelly, PharmD, Vagelos, Randall H., MD, FACC, Schreiber, Donald, MD, Fowler, Michael B., MB, FACC
Format: Article
Language:English
Subjects:
Cardiovascular
Internal Medicine
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Summary:Impact of Nesiritide on Renal Function in Patients With Acute Decompensated Heart Failure and Pre-Existing Renal Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ronald M. Witteles, David Kao, Dianne Christopherson, Kelly Matsuda, Randall H. Vagelos, Donald Schreiber, Michael B. Fowler Although nesiritide is approved for the treatment of acute decompensated heart failure, retrospective analyses have raised concerns that it may cause worsened renal function. In this randomized, double-blind, placebo-controlled clinical trial of patients with acute decompensated heart failure and baseline renal dysfunction, nesiritide administration had no impact on renal function. Although the results of this trial do not support the use of nesiritide for the purpose of protecting renal function, they do provide the first prospective evidence that nesiritide does not worsen renal function in this patient population.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.03.071