Air Pollution and Cardiovascular Injury

Air Pollution and Cardiovascular Injury: Epidemiology, Toxicology, and Mechanisms Boris Z. Simkhovich, Michael T. Kleinman, Robert A. Kloner Recent epidemiologic studies show that increased levels of air pollutants are positively associated with cardiovascular morbidity and mortality. Inhalation of...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-08, Vol.52 (9), p.719-726
Main Authors: Simkhovich, Boris Z., MD, PhD, Kleinman, Michael T., PhD, Kloner, Robert A., MD, PhD, FACC
Format: Article
Language:English
Subjects:
air pollution
Cardiovascular
cardiovascular effects
Internal Medicine
mechanisms
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Summary:Air Pollution and Cardiovascular Injury: Epidemiology, Toxicology, and Mechanisms Boris Z. Simkhovich, Michael T. Kleinman, Robert A. Kloner Recent epidemiologic studies show that increased levels of air pollutants are positively associated with cardiovascular morbidity and mortality. Inhalation of air pollutants affects heart rate, heart rate variability, blood pressure, vascular tone, blood coagulability, and the progression of atherosclerosis. Major mechanisms of inhalation-mediated cardiovascular toxicity include activation of pro-inflammatory pathways and generation of reactive oxygen species. In addition, inhaled ultrafine particles may be translocated into the circulation and transported to the vasculature and heart where they can induce cardiac arrhythmias and decrease cardiac contractility and coronary flow.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2008.05.029