Depression and Risk of Sudden Cardiac Death and Coronary Heart Disease in Women

Objectives We assessed the association between depression and sudden cardiac death (SCD) and cardiac events among individuals without baseline coronary heart disease (CHD). Background Depression is a risk factor for cardiac events and mortality among those with CHD, possibly from arrhythmia. Methods...

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Published in:Journal of the American College of Cardiology 2009-03, Vol.53 (11), p.950-958
Main Authors: Whang, William, MD, MS, Kubzansky, Laura D., PhD, MPH, Kawachi, Ichiro, MD, PhD, Rexrode, Kathryn M., MD, MPH, Kroenke, Candyce H., ScD, MPH, Glynn, Robert J., ScD, Garan, Hasan, MD, MS, Albert, Christine M., MD, MPH
Format: Article
Language:English
Subjects:
Cardiovascular
coronary disease
epidemiology
Internal Medicine
sudden cardiac death
women
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Summary:Objectives We assessed the association between depression and sudden cardiac death (SCD) and cardiac events among individuals without baseline coronary heart disease (CHD). Background Depression is a risk factor for cardiac events and mortality among those with CHD, possibly from arrhythmia. Methods We studied depressive symptoms and a proxy variable for clinical depression consisting of severe symptoms and/or antidepressant medication use and their relationship to cardiac events in the Nurses' Health Study. Questionnaires in 1992, 1996, and 2000 assessed symptoms with the Mental Health Index (MHI-5), and antidepressant use was assessed in 1996 and 2000. Primary end points included SCD, fatal CHD, and nonfatal myocardial infarction. Results Among 63,469 women without prior CHD/stroke in 1992, 7.9% had MHI-5 scores
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2008.10.060