Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension

• Published in: Journal of the American College of Cardiology 2016-07, Vol.68 (4), p.368-378
• Main Authors: Opitz, Christian F., MD, Hoeper, Marius M., MD, Gibbs, J. Simon R., MD, Kaemmerer, Harald, MD, VMD, Pepke-Zaba, Joanna, MD, Coghlan, J. Gerry, MD, Scelsi, Laura, MD, D’Alto, Michele, MD, Olsson, Karen M., MD, Ulrich, Silvia, MD, Scholtz, Werner, MD, Schulz, Uwe, MD, Grünig, Ekkehard, MD, Vizza, Carmine D., MD, Staehler, Gerd, MD, Bruch, Leonhard, MD, Huscher, Doerte, MSc, PhD, Pittrow, David, MD, Rosenkranz, Stephan, MD
• Format: Article
• Language: English
• Subjects: Cardiovascular; heart failure with preserved ejection fraction; idiopathic pulmonary arterial hypertension; Internal Medicine
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2016.05.047

Abstract Background Pulmonary hypertension (PH) is hemodynamically classified as pre-capillary (as seen in idiopathic pulmonary arterial hypertension [IPAH]) or post-capillary (as seen in heart failure with preserved ejection fraction [HFpEF]). Overlaps between these conditions exist. Some patients present with risk factors for left heart disease but pre-capillary PH, whereas patients with HFpEF may have combined pre- and post-capillary PH. Objectives This study sought to further characterize similarities and differences among patient populations with either PH-HFpEF or IPAH. Methods We used registry data to analyze clinical characteristics, hemodynamics, and treatment responses in patients with typical IPAH (