Adaptive Immunity Dysregulation in Acute Coronary Syndromes

Abstract Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2016-11, Vol.68 (19), p.2107-2117
Main Authors: Flego, Davide, PhD, Liuzzo, Giovanna, MD, PhD, Weyand, Cornelia M., MD, PhD, Crea, Filippo, MD
Format: Article
Language:English
Subjects:
Cardiovascular
Internal Medicine
outcome
pathogenesis
signaling
treatment
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Summary:Abstract Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. This review discusses recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogenic concepts.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.08.036