Nonalcoholic Fatty Liver Disease and the Heart

Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insul...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2019-03, Vol.73 (8), p.948-963
Main Authors: Stahl, Eric P., Dhindsa, Devinder S., Lee, Suegene K., Sandesara, Pratik B., Chalasani, Naga P., Sperling, Laurence S.
Format: Article
Language:English
Subjects:
cardiovascular disease
metabolic syndrome
nonalcoholic fatty liver disease
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Summary:Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolism are some of the mechanisms by which NAFLD increases the risk of CVD. Patients with NAFLD develop increased atherosclerosis, cardiomyopathy, and arrhythmia, which clinically result in cardiovascular morbidity and mortality. Defining the mechanisms linking these 2 diseases offers the opportunity to further develop targeted therapies. The aim of this comprehensive review is to examine the association between CVD and NAFLD and discuss the overlapping management approaches. [Display omitted]
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2018.11.050