Current status and future directions in Food Protein-Induced Enterocolitis Syndrome (FPIES): An NIAID Workshop Report

Food Protein-Induced Enterocolitis (FPIES) is a non-IgE mediated GI food allergy characterized by delayed, protracted vomiting, accompanied by lethargy and pallor, usually 1-4 hours following ingestion of the food allergen. The pathophysiology of FPIES remains unknown and currently there are no diag...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2024-11
Main Authors: Nowak-Wegrzyn, Anna, Sicherer, Scott H., Akin, Cem, Anvari, Sara, Bartnikas, Lisa M., Berin, M. Cecilia, Bingemann, Theresa A., Boyd, Scott, Brown-Whitehorn, Terri, Bunyavanich, Supinda, Cianferoni, Antonella, du Toit, George, Fortunato, John E., Goldsmith, Jeffrey D., Groetch, Marion, Leonard, Stephanie A., Rao, Meenakshi, Schultz, Fallon, Schwaninger, Julie M., Venter, Carina, Westcott-Chavez, Amity, Wood, Robert A., Togias, Alkis
Format: Article
Language:English
Subjects:
dysautonomia
enteroendocrine cell
food allergy
food protein-induced enterocolitis syndrome
FPIES
gut neurophysiology
mast cell
serotonin
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Summary:Food Protein-Induced Enterocolitis (FPIES) is a non-IgE mediated GI food allergy characterized by delayed, protracted vomiting, accompanied by lethargy and pallor, usually 1-4 hours following ingestion of the food allergen. The pathophysiology of FPIES remains unknown and currently there are no diagnostic biomarkers available to assess disease activity or its resolution. Over the last two decades, FPIES has become increasingly recognized in both pediatric and adult patients. Forty years later after the initial FPIES description, the first international classification of diseases (ICD-10) code for FPIES was established and the first international consensus guidelines for diagnosis and management of FPIES was published. On June 22, 2022, the National Institute of Allergy and Infectious Diseases (NIAID) held its first virtual multidisciplinary workshop on FPIES. Various clinical and translational aspects of FPIES, as well as the important areas of unmet needs were discussed as priorities for future research during this 2-day virtual workshop. The following report provides a summary of content of the workshop, including updated literature on the topic areas, as well as providing a critical commentary on the state of FPIES.
ISSN:0091-6749
DOI:10.1016/j.jaci.2024.10.022