Bipolar pharmacotherapy and suicidal behavior

Abstract Introduction Antipsychotics, particularly second generation agents, are widely used in bipolar disorder, but their effect on suicidal behavior in this population has not been systematically studied. Methods Retrospective chart review of 405 veterans with bipolar disorder followed for a mean...

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Bibliographic Details
Published in:Journal of affective disorders 2007, Vol.103 (1), p.23-28
Main Authors: Yerevanian, Boghos I, Koek, Ralph J, Mintz, Jim
Format: Article
Language:English
Subjects:
Antipsychotic drugs
Bipolar disorder
Longitudinal study
Psychiatry
Public health
Suicide
Suicide attempt
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Summary:Abstract Introduction Antipsychotics, particularly second generation agents, are widely used in bipolar disorder, but their effect on suicidal behavior in this population has not been systematically studied. Methods Retrospective chart review of 405 veterans with bipolar disorder followed for a mean of three years, with month-by-month systematic assessment of current pharmacotherapy and suicide completion, attempt or hospitalization for suicidality. Comparison of rates of suicidal events during mood stabilizer monotherapy, antipsychotic monotherapy, and combination of mood stabilizer and antipsychotic. Results Non-lethal suicide event rates were 9.4 times greater ( χ2 = 28.29, p < .0001) during antipsychotic monotherapy and 3.5 times greater during mood stabilizer + antipsychotic ( χ2 = 15.13, p = 0.0001) than during mood stabilizer monotherapy. Limitations Antipsychotics may have been prescribed because patients were at greater risk of suicidal behavior. First and second generation antipsychotics were not distinguished. Conclusions Treatment of bipolar patients with antipsychotics is associated with an increase in non-lethal suicidal behavior. Thus, use of antipsychotics for bipolar patients requires careful monitoring for suicidal behavior. Further studies are urgently needed to better characterize this relationship.
ISSN:0165-0327
DOI:10.1016/j.jad.2007.05.018