Clinical features of differential diagnosis between unipolar and bipolar depression in a drug-free sample of young adults

•This is a young adult sample with similar characteristics of patients seeking treatment in the first episodes of mood disorder.•Family history of BD, childhood trauma, and number of depressive symptoms are more frequent in bipolar depression.•Unipolar depression exhibit diurnal preference while tho...

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Bibliographic Details
Published in:Journal of affective disorders 2019-01, Vol.243, p.103-107
Main Authors: Patella, André Machado, Jansen, Karen, Cardoso, Taiane de Azevedo, Souza, Luciano Dias de Mattos, Silva, Ricardo Azevedo da, Coelho, Fábio Monteiro da Cunha
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult Survivors of Child Adverse Events - psychology
Bipolar depression
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - psychology
Cross-Sectional Studies
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - psychology
Diagnosis, Differential
Diagnostic and Statistical Manual of Mental Disorders
Differential diagnosis
Early Diagnosis
Female
Humans
Major depressive disorder
Male
Mood disorders
Unipolar depression
Young Adult
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Summary:•This is a young adult sample with similar characteristics of patients seeking treatment in the first episodes of mood disorder.•Family history of BD, childhood trauma, and number of depressive symptoms are more frequent in bipolar depression.•Unipolar depression exhibit diurnal preference while those with bipolar depression exhibit the reversed night/day cycle. Subjects with bipolar disorder suffering of a depressive episode are frequently misdiagnosed as unipolar depression, being important studies assessing the differential diagnosis between bipolar and unipolar depression. To assess the sociodemographic and clinical features of drug-free young adults in a depressive episode of bipolar or unipolar disorder in order to identify factors that may differentiate these psychiatric conditions. This is a cross-sectional study with 241 young adults aged between 18 and 29 years who were evaluated using the Structured Clinical Interview for DSM-IV (SCID). The sample comprised patients with BD (n = 89) and major depressive disorder (n = 152), experiencing a depressive episode and not using psychoactive drugs or illicit psychoactive substances. The characteristics associated with bipolar depression were being male (p 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2018.09.007