Joint symptoms in patients on bupropion therapy

Objective. – To describe joint symptoms related to bupropion therapy. Methods. – We retrospectively reviewed adverse events in bupropion-treated patients reported to the Bourgogne Drug Surveillance Center, France, between October 2001 and December 2002. Joint symptoms classified by the causality ass...

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Bibliographic Details
Published in:Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2004-11, Vol.71 (6), p.583-585
Main Authors: Ornetti, Paul, Disson-Dautriche, Anne, Muller, Géraldine, Cherasse, Anne, Tavernier, Christian, Besancenot, Jean-François, Sgro, Catherine, Maillefert, Jean-Francis
Format: Article
Language:English
Subjects:
Adult
Adverse reactions
Antidepressive Agents, Second-Generation - adverse effects
Arthralgia
Arthritis
Arthritis - chemically induced
Bupropion
Bupropion - adverse effects
Female
Humans
Joints
Male
Middle Aged
Serum Sickness - chemically induced
Serum sickness-like reactions
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Summary:Objective. – To describe joint symptoms related to bupropion therapy. Methods. – We retrospectively reviewed adverse events in bupropion-treated patients reported to the Bourgogne Drug Surveillance Center, France, between October 2001 and December 2002. Joint symptoms classified by the causality assessment as related to bupropion were identified and examined. Results. – Four cases were found. Three patients had semi-delayed hypersensitivity reactions resembling serum sickness, manifesting as urticaria and arthralgia with or without a fever. The remaining patient had an unusual presentation consisting in acute monoarthritis of the wrist that started a few days after bupropion initiation. Conclusion. – Hypersensitivity reactions to bupropion are fairly common and include rare cases of serum sickness-like reaction. Urticaria and incapacitating arthralgia are at the forefront of the clinical picture and may require a brief period of inpatient care. Antihistamines are the treatment of choice. Other manifestations such as acute monoarthritis might occur, although this awaits confirmation as we identified a single case.
ISSN:1297-319X
DOI:10.1016/j.jbspin.2003.10.004