Determination of 10 Haloacetamides in drinking water by gas chromatography with automated solid phase extraction

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2020-08, Vol.1150, p.122191, Article 122191
• Main Authors: Zhou, Run, Xu, Zhifei, Zhu, Jingying, Liu, Wenwei, Meng, Yuanhua, Zhu, Pengfei, Zhou, Weijie, Huang, Chunhua, Ding, Xinliang
• Format: Article
• Language: English
• Subjects: Acetamides - analysis; Acetamides - chemistry; Acetamides - isolation & purification; Automated solid phase extraction; Chromatography, Gas - methods; Disinfectants - chemistry; Disinfection by-products; Drinking water; Drinking Water - chemistry; Gas chromatography; Haloacetamides; Limit of Detection; Linear Models; Reproducibility of Results; Solid Phase Extraction - methods; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - chemistry; Water Pollutants, Chemical - isolation & purification
• ISSN: 1570-0232; 1873-376X
• DOI: 10.1016/j.jchromb.2020.122191

•An auto-SPE-GC-ECD method was developed for quantification of ten HAcAms in drinking water.•The solvent-, sample-, labor-saving method was fully optimized and validated.•Sixteen water samples from four WTPs were analyzed by SPE-GC-ECD. Drinking water disinfection may result in the formation of different classes of toxic disinfection by-products (DBPs). Haloacetamides (HAcAms) are an emerging class of nitrogenous DBPs (N-DBPs), which are generally more prevalent at lower concentrations in disinfected water than carbonaceous DBPs. Herein a fast, convenient, and effective method of analyzing 10 HAcAms in drinking water samples was demonstrated. This method was developed using gas chromatography /electron capture detection (GC/ECD) supplemented with automated solid phase extraction (auto-SPE). The variables for automated SPE procedures were further optimized, including the selection of SPE sorbents, types and volumes of extraction solvents, SPE washing solvents and wash times. Under optimized conditions, the instrumental linearity range was 0.5–150 μg L-1 with correlation coefficients>0.9975. The limits of detection and quantification of this method were 0.002–0.003 μg L-1 and 0.005–0.010 μg L-1, respectively. The recovery values ranged from 72.4% to 108.5%, and the relative standard deviations ranged from 3.3% to 9.1%. Therefore, the auto-SPE-GC-ECD method showed acceptable linearity and repeatability and was subsequently validated and applied to analyze 10 HAcAms in drinking water.