Early Gadolinium Enhancement for Determination of Area at Risk

• Published in: JACC. Cardiovascular imaging 2017-02, Vol.10 (2), p.130-139
• Main Authors: Hammer-Hansen, Sophia, MD, Leung, Steve W., MD, Hsu, Li-Yueh, DSc, Wilson, Joel R., MD, Taylor, Joni, BS, Greve, Anders M., MD, PhD, Thune, Jens Jakob, MD, PhD, Køber, Lars, MD, Kellman, Peter, PhD, Arai, Andrew E., MD
• Format: Article
• Language: English
• Subjects: acute myocardial infarction; area at risk; cardiac magnetic resonance; Cardiovascular; gadolinium enhancement
• ISSN: 1936-878X; 1876-7591
• DOI: 10.1016/j.jcmg.2016.04.009

Abstract Objectives The aim of this study was to determine whether early gadolinium enhancement (EGE) by cardiac magnetic resonance (CMR) in a canine model of reperfused myocardial infarction depicts the area at risk (AAR) as determined by microsphere blood flow analysis. Background It remains controversial whether only the irreversibly injured myocardium enhances when CMR is performed in the setting of acute myocardial infarction. Recently, EGE has been proposed as a measure of the AAR in acute myocardial infarction because it correlates well with T2-weighted imaging of the AAR, but this still requires pathological validation. Methods Eleven dogs underwent 2 h of coronary artery occlusion and 48 h of reperfusion before imaging at 1.5-T. EGE imaging was performed 3 min after contrast administration with coverage of the entire left ventricle. Late gadolinium enhancement imaging was performed between 10 and 15 min after contrast injection. AAR was defined as myocardium with blood flow