The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection

Amphotericin B (AMB) is used to treat both fungal and leishmanial infections, which are of major significance to human health. Clinical use of free AMB is limited by its nephrotoxicity, whereas liposomal AMB is costly and requires parenteral administration, thus development of novel formulations wit...

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Bibliographic Details
Published in:Journal of controlled release 2012-06, Vol.160 (3), p.685-691
Main Authors: Alsaadi, M., Italia, J.L., Mullen, A.B., Kumar, M.N.V. Ravi, Candlish, A.A., Williams, R.A.M., Shaw, C.D., Al Gawhari, F., Coombs, G.H., Wiese, M., Thomson, A.H., Puig-Sellart, M., Wallace, J., Sharp, A., Wheeler, L., Warn, P., Carter, K.C.
Format: Article
Language:English
Subjects:
Aerosols
Amphotericin B
Amphotericin B - administration & dosage
animal models
Animals
Antifungal Agents - administration & dosage
aspergillosis
Aspergillus
atomization
Biological and medical sciences
Cricetinae
Disease Models, Animal
Drug Carriers - administration & dosage
drugs
Female
Firefly Luciferin - administration & dosage
fungi
General pharmacology
human health
Inhalation
Leishmania
Leishmania donovani
Leishmania major
leishmaniasis
Leishmaniasis - drug therapy
Leishmaniasis - metabolism
Leishmaniasis - microbiology
liver
Liver - metabolism
Liver - microbiology
Lung - metabolism
Lung - microbiology
lungs
Medical sciences
Mesocricetus
Mice
Mice, Inbred BALB C
nephrotoxicity
niosomes
Non-ionic surfactant vesicles
parasites
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pulmonary Aspergillosis - drug therapy
Pulmonary Aspergillosis - metabolism
Pulmonary Aspergillosis - microbiology
Rats
Rats, Sprague-Dawley
Surface-Active Agents - administration & dosage
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Description
Summary:Amphotericin B (AMB) is used to treat both fungal and leishmanial infections, which are of major significance to human health. Clinical use of free AMB is limited by its nephrotoxicity, whereas liposomal AMB is costly and requires parenteral administration, thus development of novel formulations with enhanced efficacy, minimal toxicity and that can be applied via non-invasive routes is required. In this study we analysed the potential of non-ionic surfactant vesicles (NIV) given by nebulisation to deliver AMB to the lungs, liver and skin. Treatment with AMB-NIV resulted in significantly higher drug levels in the lungs and skin (p
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2012.04.004