Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells

Releasing drug molecules at their targets with high spatial and temporal accuracy could aid numerous clinical applications which require low systemic damage and low side effects. Nano-carriers of drugs are an attractive solution for such task, allowing specific accumulation in tumors and gradual rel...

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Bibliographic Details
Published in:Journal of controlled release 2012-09, Vol.162 (2), p.303-309
Main Authors: Bisker, Gili, Yeheskely-Hayon, Daniella, Minai, Limor, Yelin, Dvir
Format: Article
Language:English
Subjects:
adverse effects
Antibodies, Monoclonal, Murine-Derived - administration & dosage
Antibodies, Monoclonal, Murine-Derived - chemistry
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Biological and medical sciences
Cell Line, Tumor
Complement dependent cytotoxicity
Controlled drug release
cytotoxicity
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - chemistry
drugs
Femtosecond pulses
General pharmacology
gold
Gold - administration & dosage
Gold - chemistry
Gold nanoparticles
Humans
irradiation
Lasers
Medical sciences
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
nanocarriers
nanogold
nanospheres
Nanospheres - administration & dosage
Nanospheres - chemistry
necrosis
neoplasms
Neoplasms - therapy
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phototherapy
plasma membrane
Plasmon resonance
Rituximab
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Summary:Releasing drug molecules at their targets with high spatial and temporal accuracy could aid numerous clinical applications which require low systemic damage and low side effects. Nano-carriers of drugs are an attractive solution for such task, allowing specific accumulation in tumors and gradual release of their payload. Here, we utilize gold nanospheres conjugated to Rituximab, an anti-CD20 monoclonal antibody-based drug, for carrying and releasing the drug upon irradiation of specifically tailored femtosecond laser pulses. The released anti-CD20 molecules retain their functionality and ability of triggering the complement-dependent cytotoxicity. This effect comes in addition to cell necrosis caused by the plasmonic nanometric shock waves emanating from the nanospheres and rupturing the plasma membranes. Main advantages of the presented technique include high spatial and temporal resolution, low toxicity and high repeatability and consistency due to the morphological stability of the nanospheres. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2012.06.030