Technical and engineering considerations for designing therapeutics and delivery systems

• Published in: Journal of controlled release 2023-01, Vol.353, p.411-422
• Main Authors: Hassanzadeh, Parichehr, Atyabi, Fatemeh, Dinarvand, Rassoul
• Format: Article
• Language: English
• Subjects: Artificial Intelligence; Biological Availability; Drug delivery; Drug Delivery Systems; Electromechanical devices; Electron diffraction; Mechatronics; Optomechatronics; Pharmaceutical Preparations
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2022.11.056

The newly-emerged pathological conditions and increased rates of drug resistance necessitate application of the state-of-the-art technologies for accelerated discovery of the therapeutic candidates and obtaining comprehensive knowledge about their targets, action mechanisms, and interactions within the body including those between the receptors and drugs. Using the physics- and chemistry-based modern techniques for theranostic purposes, preparing smart carriers, local delivery of genes or drugs, and enhancing pharmaceutical bioavailability could be of great value against the hard-to-treat diseases and growing drug resistance. Besides the artificial intelligence- and quantum-based techniques, crystal engineering capable of designing new molecules with appropriate characteristics, improving the stability and bioavailability of poorly soluble drugs, and efficient carrier development could play a crucial role in manufacturing efficient pharmaceuticals and reducing the adverse events. In this context, identifying the structures and behaviors of crystals and predicting their characteristics are of great value. Electron diffraction by accelerated analysis of the chemicals and sensitivity to charge alterations, electromechanical tools for controlled delivery of therapeutics, mechatronics via fabrication of multi-functional smart products including the organ-on-chip devices for healthcare applications, and optomechatronics by overcoming the limitations of conventional biomedical techniques could address the unmet biomedical requirements and facilitate development of more effective theranostics with improved outcomes. [Display omitted] •Newly-emerged pathological conditions necessitate application of modern techniques.•Crystal engineering plays a key role in manufacturing efficient pharmaceuticals.•Mechatronics and optomechatronics could address the unmet biomedical requirements.