Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview

This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and ni...

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Published in:Journal of controlled release 2023-01, Vol.353, p.802-822
Main Authors: de Castro, Karine Cappuccio, Coco, Julia Cedran, dos Santos, Érica Mendes, Ataide, Janaína Artem, Martinez, Renata Miliani, do Nascimento, Mônica Helena Monteiro, Prata, João, da Fonte, Pedro Ricardo Martins Lopes, Severino, Patrícia, Mazzola, Priscila Gava, Baby, André Rolim, Souto, Eliana Barbosa, de Araujo, Daniele Ribeiro, Lopes, André Moreni
Format: Article
Language:English
Subjects:
Amphiphilic copolymers
Cancer therapy
Drug Delivery Systems
Drug delivery systems (DDS)
Humans
Micelles
Nanostructures (NSs)
Neoplasms - drug therapy
Pluronic
Poloxamer - chemistry
Polymers - chemistry
Self-assembly
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Summary:This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic® triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to innovative examples for improving tumor cytotoxicity while reducing side effects. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2022.12.017