Bioreactors for cell therapies: Current status and future advances

Abstract The use of bioreactors in cell therapy applications is on the rise, as clinical trials and commercialization of cell therapy–based products are moving to the forefront of treatment opportunities. This review focuses on the considerations and benefits of using bioreactors for cell therapy ma...

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Bibliographic Details
Published in:Cytotherapy (Oxford, England) England), 2017-01, Vol.19 (1), p.9-18
Main Authors: Eaker, Shannon, Abraham, Eytan, Allickson, Julie, Brieva, Thomas A, Baksh, Dolores, Heathman, Thomas R.J, Mistry, Biren, Zhang, Nan
Format: Article
Language:English
Subjects:
Advanced Basic Science
allogeneic
autologous
bioreactor
cell culture
cell therapy
Other
scale-out
scale-up
stem cell
tissue engineering
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Summary:Abstract The use of bioreactors in cell therapy applications is on the rise, as clinical trials and commercialization of cell therapy–based products are moving to the forefront of treatment opportunities. This review focuses on the considerations and benefits of using bioreactors for cell therapy manufacturing, with an emphasis on autologous versus allogenic, scalability, tissue engineering, automation and comparability and consistency in the final product. Evaluation and choice of the right bioreactor for any given process and indication is paramount when moving into scalable platforms and processes that can support the cell therapy industry's needs.
ISSN:1465-3249
1477-2566
DOI:10.1016/j.jcyt.2016.09.011