Tailoring antibiotic release for the treatment of periodontal infrabony defects using bioactive gelatin-alginate/apatite nanocomposite films

Local antibiotic delivery is preferred for treating periodontitis due to the benefits of high local drug concentration and minimal side effects. However, commercial polymeric drug delivery systems lack bioactivity and need additional bone grafting to treat the periodontal bone loss. In the present w...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2018-02, Vol.43, p.57-64
Main Authors: Madhumathi, K., Jeevana Rekha, L., Sampath Kumar, T.S.
Format: Article
Language:English
Subjects:
Bone substitutes
Calcium deficient hydroxyapatite
Degradable polymers
Nanocomposites
Periodontal infections
Sustained antibiotic release
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Summary:Local antibiotic delivery is preferred for treating periodontitis due to the benefits of high local drug concentration and minimal side effects. However, commercial polymeric drug delivery systems lack bioactivity and need additional bone grafting to treat the periodontal bone loss. In the present work, calcium deficient hydroxyapatite (CDHA) nanoparticles incorporated gelatin-alginate (GA) films were developed as antibiotic releasing bone substitutes for treating infrabony periodontal defects. CDHA nanoparticles (
ISSN:1773-2247
DOI:10.1016/j.jddst.2017.09.015