Determination of emitted particle characteristics and upper airway deposition of Symbicort® Turbuhaler® dry powder inhaler

The mass median aerodynamic diameter (MMAD) of the particle ensemble released from Symbicort® Turbuhaler® dry powder inhaler and the aerosol particle volume size distribution in a realistic upper airway was studied experimentally, assuming different inhalation waveforms. The idealized waveforms were...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2019-12, Vol.54, p.101229, Article 101229
Main Authors: Kugler, Sz, Nagy, A., Kerekes, A., Veres, M., Rigó, I., Czitrovszky, A.
Format: Article
Language:English
Subjects:
Dry power inhaler
MMAD
Numerical modeling
Particle size distribution
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Summary:The mass median aerodynamic diameter (MMAD) of the particle ensemble released from Symbicort® Turbuhaler® dry powder inhaler and the aerosol particle volume size distribution in a realistic upper airway was studied experimentally, assuming different inhalation waveforms. The idealized waveforms were determined from the breathing parameters of 25 healthy voluntary adults who inhaled through a not activated Turbuhaler® device.The amount of particles available for lung deposition was quantified by numerical simulations with the help of the stochastic lung deposition model (SLDM). It was calculated that approximately 30% of the particles released from the DPI are deposited in the upper airway. The lung deposition of the drug from the DPI was calculated to be between 16% and 59% of the nominal dose. The peak inhalation flow and the inhalation volume were found to be the main factors affecting the efficiency of the deposition, the inhalation time has also a small effect on it. The deposition of the Symbicort® Turbuhaler® in the lung as a function of tin and PIF. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2019.101229