Preparation, optimization and biological evaluation of gymnemic acid loaded niosomes against streptozotocin-nicotinamide induced diabetic-nephropathy in Wistar rats

The present study was designed to develop and evaluate the gymnemic acid (GA)-loaded niosomes against “streptozotocin-nicotinamide” (STZ-NA) induced “diabetic nephropathy” (DN) in Wistar rats. GA-loaded niosomes were formulated using the “thin-film hydration” process. Various preparations were prepa...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2019-12, Vol.54, p.101328, Article 101328
Main Authors: Singhal, Tinku, Mujeeb, Mohd, Ahad, Abdul, Aqil, Mohd, Rahman, Syed Obaidur, Najmi, Abul Kalam, Siddiqui, Waseem Ahmad
Format: Article
Language:English
Subjects:
Diabetic nephropathy
Gymnemic acid
Hyperglycemia
Niosomes
Oxidative stress
Streptozotocin
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Summary:The present study was designed to develop and evaluate the gymnemic acid (GA)-loaded niosomes against “streptozotocin-nicotinamide” (STZ-NA) induced “diabetic nephropathy” (DN) in Wistar rats. GA-loaded niosomes were formulated using the “thin-film hydration” process. Various preparations were prepared as per the “Box-Behnken design” and screened for vesicles size, zeta-potential and entrapment efficiency. Furthermore, the best final niosomes formulation was evaluated for their efficacy in controlling the DN potential in a STZ-NA induced diabetic Wistar rats. Further various biochemical tests were performed using commercially available “kits of Genx-bio health science Pvt. Ltd”. The optimized GA-loaded niosomes demonstrated vesicles size of 138.8 nm with zeta potential and entrapment efficiency of 76.9 mV and 87.5%, respectively. Administration of STZ-NA in normal rats showed significant (P 
ISSN:1773-2247
DOI:10.1016/j.jddst.2019.101328