Polydopamine modified TiO2 nanotube arrays as a local drug delivery system for ibuprofen

Dopamine with multifunctional groups exhibits excellent biological activity and self-polymerization ability, which provides active groups for secondary reaction on the different kinds of modified surface. In this study, using the ultrasonic method, dopamine polymer coatings functionalized on TiO2 na...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2020-04, Vol.56, p.101537, Article 101537
Main Authors: Li, Lifen, Xie, Chunling, Xiao, Xiufeng
Format: Article
Language:English
Subjects:
Drug delivery
Modified
Polydopamine
TiO2 nanotube arrays
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Summary:Dopamine with multifunctional groups exhibits excellent biological activity and self-polymerization ability, which provides active groups for secondary reaction on the different kinds of modified surface. In this study, using the ultrasonic method, dopamine polymer coatings functionalized on TiO2 nanotube arrays (TNTs) were successfully prepared. The obtained samples were characterized and evaluated using field-emission scanning electron microscopy (FESEM), transmission electron microscope (TEM) and atomic force microscopy (AFM), Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA). Upon dopamine self-polymerization, due to the presence of multifunctional groups, it could interact with drug molecules to efficiently enhance drug loading, prevent drug sudden release and improve sustained-release performance of the carrier. TNTs were loaded with ibuprofen (IBU) via soaking method before and after modification and its release properties were investigated. The results showed that dopamine-modified TNTs remarkably improved the loading of IBU and prolonged drug release. Notably, the biomineralization ability of the sample was also tremendously enhanced through modification of the nanotubes with polydopamine. In conclusion, dopamine-modified TNTs may be a promising approach in promoting the loading of IBU and sustained the drug release that is noticeably essential for bone implant therapies. Dopamine polymer coatings functionalized on TiO2 nanotube arrays were prepared. The results showed that dopamine-modified TNTs remarkably promoted drugs loading and prolonged drug release through adsorption or covalent bond interaction with drugs. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2020.101537