Intranasal delivery of gabapentin loaded optimized nanoemulsion for augmented permeation

• Published in: Journal of drug delivery science and technology 2020-04, Vol.56, p.101606, Article 101606
• Main Authors: Mallick, Archita, Gupta, Archita, Hussain, Afzal, Aparajay, Priyadarshi, Singh, Sneha, Singh, Sandeep Kumar, Dev, Abhimanyu
• Format: Article
• Language: English
• Subjects: Gabapentin; Improved permeation; Mucoadhesive nanoemulsion; Nasal delivery
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2020.101606

The study made an attempt to develop and optimize gabapentin loaded mucoadhesive nanoemulsion for the direct nose to brain delivery for better management of convulsion. The nanocarrier was screened based on maximum drug solubility and capmul assisted improved permeation across the blood brain barrier for rapid relief. The optimized formulations (response surface methodology) comprising of Capmul MCM C8, Smix and constant amount of the drug were characterized for particles size and size distribution, zeta potential, morphology, pH, viscosity, percent transmittance, residence time, stability, drug content, in vitro and ex vivo permeation parameters using goat nasal mucosa. Nasal cilio toxicity study was conducted using fresh goat nasal mucosal tissue. The optimized formulation (M130) had a particle size of 16.72 nm, zeta potential of −4.59 mV, percent transmittance of 99.99%, viscosity of 164.8 mPa s−1, residence time of 5 s and drug content of ˃ 97–99.8%. The mucoadhesive carbopol (0.5% and 0.7% w/v) addition increased zeta potential and globular size (