Influence of emulsifiers on the formation and in vitro anticancer activity of epirubicin loaded PLGA nanoparticles

Surfactants play an important role in preparation of nanoparticles. In this study, it was aimed to investigate the effect of surfactant type and concentration on development of epirubicin loaded Poly (d,l-lactide-coglycolide acid) (PLGA) nanoparticles. In this regard PVA, TPGS, sodium cholate and Po...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2020-12, Vol.60, p.102027, Article 102027
Main Authors: Esim, Ozgur, Bakirhan, Nurgul K., Sarper, Meral, Savaser, Ayhan, Ozkan, Sibel A., Ozkan, Yalcin
Format: Article
Language:English
Subjects:
Epirubicin
Nanoparticle
Sodium cholate
Surfactant
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Summary:Surfactants play an important role in preparation of nanoparticles. In this study, it was aimed to investigate the effect of surfactant type and concentration on development of epirubicin loaded Poly (d,l-lactide-coglycolide acid) (PLGA) nanoparticles. In this regard PVA, TPGS, sodium cholate and Poloxamer 188 were used as surfactants to prepare epirubicin loaded PLGA nanoparticles in three concentrations. It was found that the particle size of nanoparticles was varied in the range 109.6 ± 5.19 nm and 511.5 ± 23.99 nm. The size of nanoparticles was smaller when sodium cholate was used (p 
ISSN:1773-2247
DOI:10.1016/j.jddst.2020.102027