Fabrication of scaffold based on gelatin and polycaprolactone (PCL) for wound dressing application

Polymeric scaffold containing essential oil has played a significant role in the biomedical applications field. Our study aims to prepare antimicrobial and antioxidant scaffold from polycaprolactone (PCL) and gelatin (Gel) polymers incorporated with oregano oil (PCL/Gel/Oil) using electrospinning te...

Full description

Saved in:
Bibliographic Details
Published in:Journal of drug delivery science and technology 2021-06, Vol.63, p.102501, Article 102501
Main Authors: El Fawal, Gomaa, Hong, Huoyan, Mo, Xiumei, Wang, Hongsheng
Format: Article
Language:English
Subjects:
Electrospinning
Gelatin
Oregano oil
Polycaprolactone (PCL)
Wound dressing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polymeric scaffold containing essential oil has played a significant role in the biomedical applications field. Our study aims to prepare antimicrobial and antioxidant scaffold from polycaprolactone (PCL) and gelatin (Gel) polymers incorporated with oregano oil (PCL/Gel/Oil) using electrospinning technique. Fiber's morphology was changed by using oregano oil as observed by scanning electron microscopy (SEM). FTIR analysis demonstrates the presence of oregano oil in the PCL/Gel/Oil scaffold. Thermogravimetric (TG) and X-ray diffraction (X-rd) analysis Results show insignificant change for PCL/Gel scaffold's properties by using oregano oil. Cytotoxicity assay demonstrates the biocompatibility of PCL/Gel/Oil scaffold. Also, antibacterial results show significant activity against gram-negative and gram-positive bacteria. In conclusion, PCL/Gel/Oil scaffold may be a promising scaffold for wound dressing application. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2021.102501