Formulation and optimization of lemon balm extract loaded azelaic acid-chitosan nanoparticles for antibacterial applications

Herein, preparation of chitosan/azelaic acid (CsAz) nanoparticles, loaded with lemon balm extract (LBE), and optimization of the formulation by using a mathematical model is reported. The model was designed by experimental design technique (DOE) to evaluate the effect of weight ratio of chitosan to...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2021-10, Vol.65, p.102687, Article 102687
Main Authors: Tarassoli, Zohreh, Najjar, Reza, Amani, Amir
Format: Article
Language:English
Subjects:
Antibacterial
Azelaic acid
Chitosan
Chitosan-azelaic acid nanoparticles
Experimental design
Lemon balm extract
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Summary:Herein, preparation of chitosan/azelaic acid (CsAz) nanoparticles, loaded with lemon balm extract (LBE), and optimization of the formulation by using a mathematical model is reported. The model was designed by experimental design technique (DOE) to evaluate the effect of weight ratio of chitosan to azelaic acid (Cs/Az), tripolyphosphate (TPP) concentration and LBE weight on the loading efficiency of lemon balm in the chitosan nanoparticles. Data analysis from DOE indicated that the Cs/Az ratio (p-value 0.3014) exhibited no significant effect on the loading efficiency. Meanwhile, TPP concentration (p-values 0.0021) and LBE weight (p-value
ISSN:1773-2247
DOI:10.1016/j.jddst.2021.102687