Comparative acceptability of mini-tablets, fine granules, and liquid formulations in young children: An exploratory randomized crossover study

Age-appropriate paediatric formulations are needed to achieve optimal medication adherence in children. In Europe and the United States, the acceptability of mini-tablets was compared to that of liquid formulations, which are commonly used as paediatric formulations. In Japan, fine granules are also...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2022-04, Vol.70, p.103154, Article 103154
Main Authors: Miyazaki, Kazuki, Hida, Noriko, Kamiya, Taro, Yamazaki, Taigi, Murayama, Nobuhiro, Kuroiwa, Miyu, Kurata, Naomi, Ishikawa, Yoichi, Yamashita, Shinji, Nakamura, Hidefumi, Nakamura, Akihiro, Harada, Tsutomu
Format: Article
Language:English
Subjects:
Acceptability
Fine granules
Liquid formulation
Mini-tablet
Paediatric formulation
Swallowability
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Summary:Age-appropriate paediatric formulations are needed to achieve optimal medication adherence in children. In Europe and the United States, the acceptability of mini-tablets was compared to that of liquid formulations, which are commonly used as paediatric formulations. In Japan, fine granules are also commonly administered to children. This study was performed to examine the acceptability of mini-tablets, fine granules, and liquid formulations by children. This prospective, single-centre, three-period crossover, randomised controlled trial included children aged 2–8 years who were visiting a paediatric department in Showa University Hospital and had experience in taking medicine. The primary endpoint was the measure of acceptability by observation of healthcare professionals according to pre-defined evaluation criteria. Sixty-five subjects including low-aged (2–
ISSN:1773-2247
DOI:10.1016/j.jddst.2022.103154