Oral docetaxel delivery with cationic polymeric core-shell nanocapsules: In vitro and in vivo evaluation

One of the most important drawbacks in chemotherapy is the lack of effective oral self-administration of chemotherapeutics due to low oral bioavailability and instability within the gastrointestinal tract, leading to systemic side effects. The main aim of this study was to develop Docetaxel (DCX) lo...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2023-02, Vol.80, p.104163, Article 104163
Main Authors: Daşkın, Demet, Erdoğar, Nazlı, İskit, Alper B., Bilensoy, Erem
Format: Article
Language:English
Subjects:
Docetaxel
Gastrointestinal cancers
Nanocapsule
Oral chemotherapy
Polycaprolactone
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Summary:One of the most important drawbacks in chemotherapy is the lack of effective oral self-administration of chemotherapeutics due to low oral bioavailability and instability within the gastrointestinal tract, leading to systemic side effects. The main aim of this study was to develop Docetaxel (DCX) loaded polymeric nanocapsule formulations and evaluate in vitro and in vivo characteristics for local treatment of gastrointestinal cancers in comparison to DTX solution. Polycaprolactone (PCL) was the core polymer for the nanocapsules that were further coated with either polyethylene glycol (PEG) or chitosan (CS). Particle size remained within the range of 180–210 nm with a loading capacity of over 65%. Sustained release of DCX was observed within 24 h in gastrointestinal media. Cell culture studies revealed safety of blank nanocapsules. In addition, DCX nanocapsules were found to have significantly higher cytotoxicity than free DCX at the MCF-7 cell line (p 
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104163