Nano formulation approaches for curcumin delivery- a review

• Published in: Journal of drug delivery science and technology 2023-04, Vol.82, p.104326, Article 104326
• Main Authors: Gayathri, Kumararaja, Bhaskaran, Mahendran, Selvam, Chelliah, Thilagavathi, Ramasamy
• Format: Article
• Language: English
• Subjects: Co-delivery; Combinational delivery; Curcumin; Nano formulation; Targeted delivery
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2023.104326

Curcumin is a polyphenol molecule derived from Curcuma longa Linn's rhizomes. Curcumin appears to have been the target of substantial research, with cancer, viral, fungal infections, bacterial, arthritis, antioxidant, anti-inflammatory, allergies, Alzheimer's disease, and other chronic diseases and disorders all being explored. Curcumin has undesirable features such as inadequate intake and low aqueous solubility. To resolve these challenges, research has taken numerous attempts to improve its absorption, solubility, and bioavailability. Nanotechnology plays a critical role in the creation of nanostructured devices, nanomedicines, targeted therapy, and nanocarriers. Curcumin nano formulation has alleviated some of the major disadvantages of curcumin-based medication delivery. The emphasis of the study is on nano-based techniques to address therapeutic activity, efficacy, bioavailability, and solubility. Curcumin was localized to a certain cellular and molecular level by combining nano-curcumin with a specific molecule to enhance activity at the target site. A detailed description of solubility and bioavailability enhancement technique using protein carriers, solid dispersions, nanofiber, carbon dots, liposomes, and polymer carrier drug delivery systems is provided in this review. [Display omitted]