Sirolimus loaded chitosan functionalized PLGA nanoparticles protect against sodium iodate-induced retinal degeneration

Age-related macular degeneration (AMD) is a major health concern in the ageing human population. Though existing therapeutics have shown some efficacy, low retinal bioavailability of drugs continues to be a hindrance in ocular drug delivery system. Sirolimus (SIR) is one such drug. In this study, we...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2023-04, Vol.82, p.104369, Article 104369
Main Authors: Suri, Reshal, Nag, Tapas C., Mehra, Nikita, Neupane, Yub Raj, Shafi, Sadat, Sharma, Devyani, Sharma, Kalicharan, Sultana, Yasmin, Kohli, Kanchan
Format: Article
Language:English
Subjects:
Age-related macular degeneration
Chitosan
PLGA
Sirolimus
Sodium iodate
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Summary:Age-related macular degeneration (AMD) is a major health concern in the ageing human population. Though existing therapeutics have shown some efficacy, low retinal bioavailability of drugs continues to be a hindrance in ocular drug delivery system. Sirolimus (SIR) is one such drug. In this study, we developed chitosan functionalized PLGA nanoparticles (NP), (
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104369