Biological screening of divalent transition metal decanoates owning powerful antimicrobial and cytotoxic properties

The prevalence of antimicrobial resistance (AMR) is on the rise worldwide as it is an emerging global health challenge of our time. The antimicrobial resistance of the bacteria reduces antibiotic efficiency and increases bacterial morbidity and mortality. To combat the current epidemic of antibiotic...

Full description

Saved in:
Bibliographic Details
Published in:Journal of drug delivery science and technology 2023-06, Vol.84, p.104428, Article 104428
Main Authors: Govindarajan, Kavitha, Perumalswamy sekar, Parasuraman, Ramasamy, Karthikeyan, Ezhumalai, Dhineshkumar, Rajasekhar Kavitha, Rashika, Parasuraman, Vijayarohini
Format: Article
Language:English
Subjects:
Antibacterial activity
Antifungal activity
Antimicrobial resistance
Co-ordination metal complexes
Cytotoxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The prevalence of antimicrobial resistance (AMR) is on the rise worldwide as it is an emerging global health challenge of our time. The antimicrobial resistance of the bacteria reduces antibiotic efficiency and increases bacterial morbidity and mortality. To combat the current epidemic of antibiotic-resistance infections, alternative antibiotics must be developed. An investigation of antibacterial potential was conducted using a novel coordination compound synthesized from transition divalent metal ions with the decanoic acid ligand. Spectroscopic techniques, namely UV–Visible, and FT-IR were used to confirm the complex formation. The unique morphologies and elemental composition of metal decanoates are analyzed with a scanning electron microscope (SEM). All the metal complexes were tested for antibacterial activity against Escherichia coli, Klebsilla pneumonia, Staphylococcus aureus, and Streptococcus mutans using the agar well diffusion method. Mn(II), Ni(II), and Zn(II) metal decanoates showed promising results as better bactericidal agents against both Gram positive and negative bacterial strains due to the chelation mechanism. In addition, the antifungal effect against Candida albicans was also investigated, wherein all the metal complexes showed enhanced performance. Cell viability of metal decanoates and ligand was examined by MTT assay using HeLa cervical cancer cell line. Thus, these findings promote metal decanoate complexes as a potential candidate for practical applications for ongoing antimicrobial resistance. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104428